| Bioactivity | [DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1]. | ||||||
| Invitro | [DPro5] Corticotropin Releasing Factor, human, rat TFA（1 nM；1 小时）可降低海马群体峰值的幅度并防止长时程增强 (LTP) 的发生[2]。 0 --> [DPro5] Corticotropin Releasing Factor, human, rat TFA 相关抗体: | ||||||
| In Vivo | [DPro5] Corticotropin Releasing Factor, human, rat TFA（0.01-1 μg；静脉注射；单剂量）不会诱导典型的焦虑作用，但会对 Sprague-Dowley 大鼠产生非特异性行为抑制[1]。 Animal Model: | ||||||
| Name | [DPro5] Corticotropin Releasing Factor, human, rat TFA | ||||||
| Sequence | Ser-Glu-Glu-Pro-{d-Pro}-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2 | ||||||
| Shortening | SEEP-{d-Pro}-ISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 | ||||||
| Formula | C208H344N60O63S2.xC2HF3O2 | ||||||
| Molar Mass | 4757.45 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
||||||
| Reference | [1]. Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian. [2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7. |
[DPro5] Corticotropin Releasing Factor, human, rat TFA
CAS: F: C208H344N60O63S2.xC2HF3O2 W: 4757.45 (free base)
Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist.
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.